Long segments of RNA? encoded in our DNA but not translated into protein?are key to physically manipulating DNA in order to activate certain genes, say researchers at The Wistar Institute. These non-coding RNA-activators (ncRNA-a) have a crucial role in turning genes on and off during early embryonic development, researchers say, and have also been connected with diseases, including some cancers, in adults.
In an online article of the journalNature, a team of scientists led by Wistar's Ramin Shiekhattar, Ph.D., detail the mechanism by which long non-coding RNA-activators promote gene expression. They show how these RNA molecules help proteins in the cell to create a loop of DNA in order to open up genes for transcription. Their experiments have also described how particular ncRNA-a molecules are related to FG syndrome, a genetic disease linked to severe neurological and physical deficits. "These ncRNA-activators can activate specific genes by working with large protein complexes, filling in a big piece of the puzzle," said Shiekhattar, Herbert Kean, M.D., Family Professor and senior author of the study. "Our DNA encodes thousands of these ncRNA-activators, each with a role in timing the expression of a specific gene. As we learn more about non-coding RNA, I believe we will have a profoundly better understanding of how our genes function."
Their findings also provide a plausible mechanism of how locations along chromosomes, classically known as "enhancer" elements, can influence the expression ("reading") of genes located 5,000 to 100,000 base pairs ("letters") of DNA away. According to their findings, ncRNA-a molecules bind to large protein complexes to form a loop of DNA, which then opens up the gene to the molecular machinery that transcribes DNA. "There is an abundance of evidence to indicate that enhancers are critical components of transcription during embryonic development and disease process," Shiekhattar said.
"Non-coding RNAs are probably one of the earliest molecules that determine spatial and temporal gene expression in a developing embryo," Shiekhattar said. "These enhancers can help turn genes on and off as a growing embryo would need, but as we have seen in other genetic mechanisms of embryonic development, they can lead to cancer if they are switched on inappropriately in adult cells."
In the classic "central dogma" of biology, chromosomal DNA is transcribed into RNA, which is then translated by the cell into proteins. In recent years, however, scientists have found that not all transcribed RNA molecules become translated into proteins. In fact, studies have shown that large portions of the genome are transcribed into RNA that serve tasks other than functioning as blueprints for proteins. In 2010, the Shiekhattar lab first published the discovery of these ncRNA enhancer molecules in the journalCell(2010 Oct 1;143(1):46-58), and theorized on their role as "enhancers" of gene expression. Since then, laboratories around the world have published and linked ncRNAs not only to transcriptional enhancers but also to certain diseases, including some cancers.
To discover how such enhancer-like RNAs function, the Shiekhatter laboratory deleted candidate molecules with known roles in activating gene expression, and assessed if they were related to RNA-dependent activation. They found that depleting components of the protein complex known as Mediator specifically and potently diminished the ability of ncRNA-a to start the process of transcribing a gene into RNA. Further, they found that these activating ncRNAs can attach to Mediator at multiple locations within the Mediator protein complex, and Mediator itself can interact with the enhancer element site on DNA that encodes these activating ncRNAs. Their results also determined how mutations in a protein that makes up the Mediator complex, called MED12, drastically diminishes Mediator's ability to associate with activating ncRNAs.
Mutations in the MED12 protein are a marker for FG syndrome (also know as Opitz?Kaveggia syndrome), a rare genetic disorder that leads to abnormalities throughout the body and varying degrees of physical and neurological problems. "This clearly shows how activating ncRNAs can influence disease development, an idea that has been gaining evidence in the scientific literature," Shiekhattar said. To confirm that ncRNA-a works with Mediator to form a loop in DNA, the researchers used a technique called chromosome conformation capture (3C) to gain a better understanding of the three-dimensional structure of chromosomes. Their results show how Mediator gets a foothold of sorts on the portion of DNA that encodes the ncRNA-a, and twists the DNA to form a loop.
"The looping mechanism serves to physically bring together a distant enhancer element with the start site of the targeted gene, allowing Mediator to recruit the proteins responsible for reading the gene to the location," Shiekhattar said. "It is at least one answer to how these classical enhancer elements function while being physically distant from their target genes."
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The Wistar Institute: http://www.wistar.org
Thanks to The Wistar Institute for this article.
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How you feel about the Canon Pixma iP7220 Wireless Inkjet Photo Printer will depend largely on how focused you are on output quality. Compared with the Editors' Choice HP Officejet 6100 ePrinter, for example, it's slower, has a lower paper capacity, and offers fewer features. On the other hand, it delivers notably better output quality, with better text and photos than most ink jets. If output quality is your key concern, that's enough to make it a strong contender for home or light-duty personal use in any size office.
In addition to its high-quality output, the iP7220 offers a few features that go beyond the basics, but not by much. As the name suggests, it supports Wi-Fi, for example, and it also supports AirPrint. However, there's no Ethernet support, so Wi-Fi is your only choice for connecting to a network, and there's no Wi-Fi Direct, so you can't connect directly to the printer from your smartphone or tablet.
Paper handling is limited, but better than you might expect at this price. The 125-sheet input capacity is supplemented by a photo tray that can hold 20 sheets of 4 by 6 photo paper, which means you can print photos without having to swap out paper in the main tray. Two other noteworthy extras are the automatic duplexer (for printing on both sides of a page) and the ability to print on printable optical discs, although you may have to check the onscreen manual to figure out where the disc printing options are hidden in the software that ships with the printer.
Setup and Speed Setting up the iP7220 was standard fare. For my tests, I connected it by USB cable to a system running Windows Vista. The speed for business applications is best described as a little slow but within a tolerable range for a home or home office printer. On our business applications suite, I timed it (using QualityLogic's hardware and software for timing) at an effective 2.5 pages per minute (ppm), making it only about 70 percent as fast as the Officejet 6100 ePrinter, at 3.6 ppm, and even slower compared with the slightly more expensive Editors' Choice Epson WorkForce 60, at 4.1 ppm.
Making up somewhat for the speed for business applications is the printer's photo speed, which averages a reasonably fast 1 minute 5 seconds for a 4 by 6. That makes it essentially tied with the Officejet 6100 for photo speed, and about twice as fast as the WorkForce 60.
Output Quality Also helping to make up for the slow speed for business applications is that the output quality is above par overall, with better text and photo quality than most inkjets and par quality graphics. The text isn't quite a match for a typical laser, and I wouldn't use it for, say, a resume. However, its far more readable at small font sizes that most ink jets can manage, and it's good enough for almost any business use.
Graphics quality is dead on par for an inkjet, which makes it easily good enough for any internal business use, including PowerPoint handouts. As with many printers, the iP7220 has a tendency to lose thin lines against a solid dark background, but depending on how critical an eye you have, you may consider the quality good enough for output going to an important client or customer. Photo quality is in the top tier for inkjets that aren't aimed specifically at photo enthusiasts or professionals, which makes them noticeably better than the photos you'll get from many drug stores.
As may be obvious, the most convincing argument for this printer is its output quality, with better looking text and photos than most inkjets deliver, and reasonably good-looking graphics output as well. If you don't need the high quality output, the HP Officejet 6100 will give you faster speed and more features for the price, but if output quality matters more, the Canon Pixma iP7220 Wireless Inkjet Photo Printer will likely be your preferred choice.
More Ink Jet Printer Reviews: ??? Canon Pixma iP7220 Wireless Inkjet Photo Printer ??? HP Officejet Pro X576dw MFP ??? HP Officejet Pro X551dw Printer ??? Epson Expression Photo XP-850 Small-in-One ??? Epson WorkForce WF-3540 ?? more
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Just how durable is the iPhone 5 over the long haul? Zollotech conducts a long-term check of the anodized aluminum and its "chippability": http://bit.ly/12Zl5cu
Sony intends to offer technology that will allow users to stream PlayStation 3 games on its forthcoming PlayStation 4 console, according to the Wall Street Journal. This latest speculation surrounding the next generation of the popular video game console comes ahead of its expected revelation in New York later this week.
According to the report, "people familiar with the company?s plans" have said that the new system will enable users to play games delivered over the Internet and is designed to use current PlayStation 3 titles, in addition to the ability to play new games stored on standard optical discs. The report also points out that the move doesn?t come as much of a surprise since Sony acquired Gaikai, a company that used to offer light-weight streaming games, last July.
The introduction of streaming titles could prove to be very significant, potentially ushering in the introduction and rise of cloud gaming, giving gamers direct access to a wide range of titles across devices. The system will also make it possible for Sony to introduce its own online game rental service.
Sony declined to comment on the rumour. Stay tuned to ITProPortal, where we'll be covering news of the announcement on 20 January.
MISHAWAKA ? In a meet in which it was hard to stand out, South Bend St. Joseph senior Trevor Carroll showed how ready he is to head back to the IHSAA State Championships next week.
Carroll left the Penn pool with three firsts, including the distinction as the only double individual winner from the Penn Sectional Saturday.
Carroll will return to defend his state title in the 200 freestyle after winning that event Saturday before he turned in virtuoso performances in his other two victories.
Penn took the team title, its fourth straight, with 521 points. St. Joseph finished second with 447.
The sectional field proved to be the deepest, at least since the middle of the last decade, as seven sectional and five pool records were set. Also, there were multiple qualifiers in five events.
?This is the fastest the sectional has been in my career,? Carroll said. ?It was fun to be a part of this.?
Carroll opened the day with a 1:41.03 clocking to win the 200 free. While an outstanding time, it was over two seconds slower than his sectional record time of a year ago.
Carroll, however, won the 500 free in an outstanding 4:27.55 effort. That shattered the sectional record by more than 13 seconds and broke the pool record (4:31.25) set in 1998.
?It just felt awesome,? said Carroll. ?I felt most of the season I wanted to swim this event, but I wanted to do what was best for the team first. Our sprinters came along great, so that opened up the 500 for me.?
He brought the rest of the field along as well, as the next three finishers (in order, Penn?s Bowen Anderson, Riley?s James Salmon and Penn?s Hudson Bursch) all beat the state qualifying time.
After helping St. Joe to second in the 200 free relay (in which the Indians qualified, as well), Carroll finished the day by anchoring the 400 free relay.
Penn had a solid lead through the first three legs of the race, leaving its anchor, Seamus Lucero-Dixon, with a body-length lead. Carroll, however, made that up during the first 50 yards, then brought home a sectional and pool record time of 3:09.87. Billy Miller, Anthony Kolbus and Andre Marin swam the first three legs.
?When I anchor relays,? Carroll explained, ?I don?t look where anyone else is at during the first half. I just swim my race. After that, I just wanted to hold off (Lucero-Dixon) and we got a school record out of it, too.?
Penn also qualified with a 3:11.44 clocking, capping a banner day for the Kingsmen.
Penn opened the meet with a sectional and pool record in the 200 medley relay as the Anderson brothers (Tanner and Bowen) joined Mate Kovacs and Lucero-Dixon to win in 1:34.65.
Tanner Anderson came back to win the 200 IM (1:55.39) before Kovacs took the 50 free (:21.86) to give the Kingsmen firm control in the team standings.
From there Penn came through with four firsts. Bowen Anderson (a sophomore) won the 100 butterfly in a sectional and pool record time of :50.37, followed by Lucero-Dixon, who took care of the 100 free (:47.63). The 200 free relay of Tanner Anderson, Kovacs, Travis Bavar and Lucero-Dixon set Penn?s final sectional and pool record of the day with a 1:25.96 time before freshman Kyle Morris won the 100 backstroke in :54.34.
?We?re right on track for next week,? Penn coach Jess Preston said. ?We kept Seamus and Mate to just one individual event so they could help us in the relays and Tanner and Bowen were outstanding for us. We wanted to get them through in four events and they got it done.?
The final new sectional mark came from St. Joe?s Chris Bals, who took the 100 breaststroke in :57.36.
Source: sermonaudio.com | 2013-02-16 - 9?hours ago
A new MP3 sermon from Burning Bush Audio Archive is now available on SermonAudio.com with the following details:
Title: Sorrow that brings joy, Pt 3
Speaker: Rev. Ivan Foster
Broadcaster: Burning Bush Audio Archive
Event: Sunday - AM
Date: 12/21/1997
Bible: 2 Corinthians 7:2-16
Length: 58 min. (16kbps)
MOSCOW (Reuters) - The Group of 20 nations declared on Saturday there would be no 'currency war' and deferred plans to set new debt-cutting targets in an indication of concern about the fragile state of the world economy.
Japan's expansive policies, which have driven down the yen, escaped criticism in a statement thrashed out in Moscow by financial policymakers from the G20, which groups developed and emerging markets and accounts for 90 percent of the world economy.
After late night talks, finance ministers and central bankers agreed on wording closer than expected to a joint statement issued last Tuesday by the Group of Seven rich nations backing market-determined exchange rates.
A draft communique seen by delegates on Friday had steered clear of the G7's call for economic policy not to be targeted at exchange rates. But the final version included a G20 commitment to refrain from competitive devaluations and stated monetary policy would be directed at price stability and growth.
"The language has been strengthened since our discussions last night," Canadian Finance Minister Jim Flaherty told reporters. "It's stronger than it was, but it was quite clear last night that everyone around the table wants to avoid any sort of currency disputes."
The communique did not single out Japan for aggressive monetary and fiscal policies that have seen the yen drop 20 percent, a trend that may now continue.
"The market will take the G20 statement as an approval for what it has been doing -- selling of the yen," said Neil Mellor, currency strategist at Bank of New York Mellon in London. "No censure of Japan means they will be off to the money printing presses."
The statement reflected a substantial, but not complete, endorsement of Tuesday's statement by the G7 nations - the United States, Japan, Britain, Canada, France, Germany and Italy.
"We all agreed on the fact that we refuse to enter any currency war," French Finance Minister Pierre Moscovici told reporters.
NO FISCAL TARGETS
The text also contained a commitment to credible medium-term fiscal strategy, but stopped short of setting specific goals.
A debt-cutting pact struck in Toronto in 2010 will expire this year if leaders fail to agree to extend it at a G20 summit of leaders in St Petersburg in September.
European Economic and Monetary Affairs Commissioner Olli Rehn said he expected concrete debt targets to be agreed at the September meeting.
"We have a common view on the need to have a credible medium-term plans for fiscal consolidation, which is also essential so we have foundation for sustainable growth," he told Reuters.
The United States says it is on track to meet its Toronto pledge but argues that the pace of future fiscal consolidation must not snuff out demand. Germany and others are pressing for another round of binding debt-cutting goals.
Backing in the communique for the use of domestic monetary policy to support economic recovery reflected the U.S. Federal Reserve's commitment to monetary stimulus through quantitative easing, or QE, to promote recovery and jobs.
QE entails large-scale bond buying -- $85 billion a month in the Fed's case -- that helps economic growth but creates money, much of which has leaked into emerging markets, threatening to destabilize them.
That was offset in the communique by a commitment to minimize "negative spillovers" of the resulting financial flows that emerging markets fear may pump up asset bubbles and ruin their export competitiveness.
"Major developed nations (should) pay attention to their monetary policy spillover," Vice Finance Minister Zhu Guangyao was quoted by state news agency Xinhua as saying in Moscow.
"Major developed countries' implementation of excessively relaxed currency policy has an influence on the world economy."
Russia, this year's chair of the G20, said the group had failed to reach agreement on medium-term budget deficit levels and also expressed concern about ultra-loose policies that it and other big emerging economies say could store up trouble for later.
Finance Minister Anton Siluanov said a rebalancing of global growth required more than an adjustment of exchange rates.
"Structural reforms in all countries, either with a positive or negative balance of payments, should play a bigger role," he said in an address to Saturday's talks.
The G20 put together a huge financial backstop to halt a market meltdown in 2009 but has failed to reach those heights since. At successive meetings, Germany has pressed the United States and others to do more to tackle their debts. Washington in turn has urged Berlin to do more to increase demand.
On currencies, the G20 text reiterated its commitment last November, "to move more rapidly toward mores market-determined exchange rate systems and exchange rate flexibility to reflect underlying fundamentals, and avoid persistent exchange rate misalignments".
It said disorderly exchange rate movements and excess volatility in financial flows could harm economic and financial stability.
(Additional reporting by Gernot Heller, Lesley Wroughton, Maya Dyakina, Tetsushi Kajimoto, Jan Strupczewski, Lidia Kelly, Katya Golubkova, Jason Bush, Anirban Nag and Michael Martina. Writing by Douglas Busvine. Editing by Timothy Heritage/Mike Peacock)
Many believe that Windows 8 is an operating system that?s yet to excite, but without any official sales figures, nobody actually knows for sure whether it?s a successful product or not.
Research firm Gartner revealed that PC sales in Western Europe dropped 11.7 percent in Q4 2012, with Windows 8 having almost no impact on shipments.
Of course, most analysts expected Windows 8 to boost sales of the hardware industry, but the lack of interest in the new software doesn?t help the PC sector post a significant recovery.
Principal research analyst at Gartner Ranjit Atwal told V3 that people are mostly interested in tablets these days, so Windows 8 is only recording good sales in the enterprise market.
?Consumers are not interested in PCs ? Windows 8 or otherwise, while professional users are still migrating to Windows 7,? he said.
Microsoft, on the other hand, continues to praise its new operating system, claiming that the 60 million sold copies are in line with those recorded by Windows 7 more than three years ago.
Newswise ? MAYWOOD, Ill. ? Though the number of cases of flu seems to be on the decline there are still numerous viruses wreaking havoc on people?s daily lives. From the stomach bug to respiratory illnesses it can be difficult to get out of bed, let alone maintain your fitness routine.
?Regular exercise is a great way to reduce stress and sleep better at night. This helps boost your immune system. However, vigorous exercise and extreme conditioning can have a negative impact on your health if you?re sick. When fighting a viral illness, it?s best to keep your exercise session short and not as intense. If you have a fever or stomach bug it might be best to hold off,? said Joe Berg, personal trainer and fitness specialist at Loyola Center for Health.
When appropriate, he suggests some exercises that can help you slowly work back into your fitness routine. These include light aerobics, like walking and cycling at an easy pace, planks, glute bridges, body weight squats and push-ups.
?These exercises cover the major muscles of the body and when performed in moderation, can help boost your immune system,? Berg said.
We all know the importance of wiping down machines and washing our hands often while at the gym. Still, for some, skipping the gym during a viral outbreak to avoid contact with infected people may seem like best option.
Valerie Walkowiak, medical integration coordinator at the Loyola Center for Fitness, gives some ideas for how to keep up your fitness routine until you feel it?s safe to go back to the gym.
?Weather permitting, it?s always great to just get out of the house and walk or run to get in some cardio exercise. Just make sure you wear the proper clothes to keep warm. This includes layers of clothing, a hat, scarf, gloves and appropriate shoes,? Walkowiak said.
If you don?t have exercise equipment in the house and the weather makes it impossible to exercise outside she suggests climbing up and down a staircase, jogging in place or performing jumping jacks.
If you?re looking for a little more, she suggests creating your own circuit training exercises. This includes 2-3 minutes of cardio exercise alternated by 30-60 seconds of strength-training exercise to get your heart rate up.
Here are some examples: ? Climb up and down a staircase for 2 minutes then switch to push-ups for 30 seconds. ? Jog in place for 2 minutes then switch to seated rows for 30 seconds ? Jumping jacks for 2 minutes followed by squats for 30 seconds ? Step up using the bottom of the staircase for 2 minutes then switch to heel raises for 30 seconds.
?You don?t have to have dumbbells, bands or tubing to get in some strength training at home. Try using household items to add resistance such as soup cans, gallon jugs of water or your own body weight,? Walkowiak said.
She suggests the following exercises to target all the muscle groups: ? Push-ups on the floor or against a wall will work your chest, the front of your shoulders and triceps muscles. ? Seated or standing row exercises using soup cans to work your back, rear shoulders and biceps muscles ? Squats, sit-to-chair stand or lunges to work your legs, glutes and core muscles. ? Heel raises on the edge of a step to work your calf muscles ? Planks, abdominal crunches, abdominal twists and leg raises to work your core muscles ? Biceps curls using soup cans ? Triceps kickbacks or over presses using soup cans or a weighted object
For media inquires, please contact Evie Polsley at epolsley@lumc.edu or call (708) 216-5313 or (708) 417-5100.
The Loyola University Chicago Health Sciences Division (HSD) advances interprofessional, multidisciplinary and transformative education and research while promoting service to others through stewardship of scientific knowledge and preparation of tomorrow's leaders. The HSD is located on the Health Sciences Campus in Maywood, Illinois. It includes the Marcella Niehoff School of Nursing, the Stritch School of Medicine, the biomedical research programs of the Graduate School, and several other institutes and centers encouraging new research and interprofessional education opportunities across all of Loyola University Chicago. The faculty and staff of the HSD bring a wealth of knowledge, experience, and a strong commitment to seeing that Loyola's health sciences continue to excel and exceed the standard for academic and research excellence. For more on the HSD, visit LUC.edu/hsd.
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This year with Valentine?s Day on a Thursday, locals and visitors can stretch love and romance out over four days of chocolate-dipped strawberries, red roses, lacy lingerie and lascivious lotions. On Thursday as hearts flutter and doves coo, it also will be the busiest day for our wedding chapels -- more than 1,000 marriage licenses have been requested as of Tuesday.
If you don?t have a Valentine, if you don?t have a wedding, then party princess Tiffany Masters has the solution with her wedding crashers party for the world?s largest wedding reception at Bagatelle adjacent to Tropicana. Every couple marrying or renewing vows here Thursday is invited to her bliss bash.
Tiffany?s bucket-list company opens it to every man who?s fantasized about crashing a wedding and running off with a bridesmaid and to every woman who?s dreamed of finding the perfect groomsman. Tiffany is an ordained minister, so she will marry any crashers on the spot in a 3-minute ceremony that?s valid for 24 hours -- and their wedding party is built in with everybody else?s celebration.
There will be an 11 p.m. bouquet toss with prizes hidden in the flowers and at midnight a garter toss. Those won?t come off the legs of the bridesmaids but instead will be shot out of confetti cannons.
Love is in the air -- love is everywhere Thursday, and even the supermodels from the Sports Illustrated Swimsuit Issue, among them Kate Upton and Katherine Webb, will party on The Strip. In honor of love, here is a special edition of the Royal Robin Rundown fired from Cupid?s arrow:
The sexiest show on The Strip, ?Zumanity? by Cirque du Soleil at New York-New York, adds two performances and drops the ticket price to $50 for Valentine?s and includes a free cocktail.
The Viva Vision show on Fremont Street Experience features ?Heart: Crazy on Vegas.?
Collective Zoo holds its second annual ?Love and Lust Sleepover? at Artisan.
Heraea at the Palms throws a dating game singles party in a quest to find love.
For the first time, The Neon Museum offers a one-hour, $777 ?Walk Thru Wedding? among the boneyard of illuminated yesteryear signs.
Downtown?s Mob Museum celebrates its first anniversary with commemorative collectible pins to the first 1,000 guests.
Flamingo headliner George Wallace, now in his ninth year here, shows his love by offering all active first responders from police, emergency and firefighter departments a free ticket to use any time before year?s end.
?Defending the Caveman? star Kevin Burke is offering a $75 package that includes two tickets for his Harrah?s show with a VIP upgrade and dinner for two at chef Kerry Simon?s nearby KGB.
?X Burlesque? at Flamingo is trimming $10 off tickets when one whispers ?Sweetheart Deal,? while ?Fantasy? at the Luxor has a dinner package at Rice & Company or Tacos & Tequila, followed by the adult revue and a gift of their 2013 Barely Bejeweled calendar.
If food is the key to a man?s heart, then remember that chef Andre Rochat, now in his 33rd year here, owns two of the most romantic restaurants in town -- Andrea?s at Monte Carlo and Alize at Palms. He has a seven-course tasting with cognac flights and post-dinner cigars. Steve Wynn?s wife Andrea has created a ?Look of Love? menu at Andrea?s in the Encore that includes oysters and caviar. Our friend cookbook author and pastry chef Megan Romano has chocolate-dipped strawberries, chocolate champagne truffles and chocolate raspberry tortes at her Chocolate & Spice on West Sahara.
Chef and Michelin Star winner Guy Savoy has flown in from Paris to serve his 10-course meal, also including oysters and caviar. Gordon Ramsay has caviar on his four-course menu with the Scotch eggs. Serendipity 3 at Caesars Palace offers an ?Adam and Eve Menu? that includes Garden of Eden sweetheart delights with Aphrodite angel hair and ends with ?Cupid?s molten chocolate.? Check out Las Vegas Sun colleague Allison Duck?s extensive Valentine?s Day dining guide.
Mandarin Oriental is offering a month of romance that includes a sultry stay. The $1,500 Suite Seduction features an art of romance spa treatment in a soaking tub for two; decadent delicacies with aphrodisiac ingredients served in the privacy of the suite; and a romance concierge who will provide candles, rose petals, music and movies from Kiki De Montparnasse at Crystals.
There?s a ?Secret Agent 702? experience for couples wanting to explore their inner sexy spy. Papillon Helicopters has a $6,800 package that includes disguises, Ferrari road-racing sports cars at Las Vegas Motor Speedway, a 3,800-feet cable zipline adventure and a 5 a.m. private helicopter tour of the Grand Canyon with champagne and strawberries for breakfast on a private plateau overlooking the Colorado River. And Eli Roth?s Goretorium gets into the mood with the debut of his Love & Music series with an all-female DJ lineup of Miss Joy, Miyuki, Crykit and the Vinylist in Baby Dolls Lounge.
The Sports Illustrated Swimsuit Issue supermodels celebrate Valentine?s Day at 1 OAK in The Mirage. Hyde Bellagio honors ?Singles Awareness Day? teamed up with Match.com to help 300 Las Vegas singles find true love on the magical night. And ladies who wear black lingerie receive a two-hour open bar at Tao?s ?Cupid Is Stupid? anti-Valentine?s party.
May love, lust and romance be with you and your significant other. The rose is red, the violet is blue, the honey is sweet, and so are you -- an English nursery rhyme from 1784 still valid today.
Robin Leach has been a journalist for more than 50 years and has spent the past decade giving readers the inside scoop on Las Vegas, the world?s premier platinum playground.
Follow Robin Leach on Twitter at Twitter.com/Robin_Leach.
Follow Vegas DeLuxe on Twitter at Twitter.com/vegasdeluxe.
Follow VDLX Editor Don Chareunsy on Twitter at Twitter.com/VDLXEditorDon.
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Valentine's Day in Las Vegas: Tubs for two, romance concierge, lacy lingerie and wedding crashers party - Las Vegas Sun News
Las Vegas Sun
Amit Dadlaney
Ashton, Tracey, Mariah and Soolin at the 2013 ?Fantasy? calendar release party at LAX in the Luxor on Saturday, Nov. 10,?2012.
This year with Valentine?s Day on a Thursday, locals and visitors can stretch love and romance out over four days of chocolate-dipped strawberries, red roses, lacy lingerie and lascivious lotions. On Thursday as hearts flutter and doves coo, it also will be the busiest day for our wedding chapels -- more than 1,000 marriage licenses have been requested as of Tuesday.
If you don?t have a Valentine, if you don?t have a wedding, then party princess Tiffany Masters has the solution with her wedding crashers party for the world?s largest wedding reception at Bagatelle adjacent to Tropicana. Every couple marrying or renewing vows here Thursday is invited to her bliss bash.
Tiffany?s bucket-list company opens it to every man who?s fantasized about crashing a wedding and running off with a bridesmaid and to every woman who?s dreamed of finding the perfect groomsman. Tiffany is an ordained minister, so she will marry any crashers on the spot in a 3-minute ceremony that?s valid for 24 hours -- and their wedding party is built in with everybody else?s celebration.
There will be an 11 p.m. bouquet toss with prizes hidden in the flowers and at midnight a garter toss. Those won?t come off the legs of the bridesmaids but instead will be shot out of confetti cannons.
Love is in the air -- love is everywhere Thursday, and even the supermodels from the Sports Illustrated Swimsuit Issue, among them Kate Upton and Katherine Webb, will party on The Strip. In honor of love, here is a special edition of the Royal Robin Rundown fired from Cupid?s arrow:
The sexiest show on The Strip, ?Zumanity? by Cirque du Soleil at New York-New York, adds two performances and drops the ticket price to $50 for Valentine?s and includes a free cocktail.
The Viva Vision show on Fremont Street Experience features ?Heart: Crazy on Vegas.?
Collective Zoo holds its second annual ?Love and Lust Sleepover? at Artisan.
Heraea at the Palms throws a dating game singles party in a quest to find love.
For the first time, The Neon Museum offers a one-hour, $777 ?Walk Thru Wedding? among the boneyard of illuminated yesteryear signs.
Downtown?s Mob Museum celebrates its first anniversary with commemorative collectible pins to the first 1,000 guests.
Flamingo headliner George Wallace, now in his ninth year here, shows his love by offering all active first responders from police, emergency and firefighter departments a free ticket to use any time before year?s end.
?Defending the Caveman? star Kevin Burke is offering a $75 package that includes two tickets for his Harrah?s show with a VIP upgrade and dinner for two at chef Kerry Simon?s nearby KGB.
?X Burlesque? at Flamingo is trimming $10 off tickets when one whispers ?Sweetheart Deal,? while ?Fantasy? at the Luxor has a dinner package at Rice & Company or Tacos & Tequila, followed by the adult revue and a gift of their 2013 Barely Bejeweled calendar.
If food is the key to a man?s heart, then remember that chef Andre Rochat, now in his 33rd year here, owns two of the most romantic restaurants in town -- Andrea?s at Monte Carlo and Alize at Palms. He has a seven-course tasting with cognac flights and post-dinner cigars. Steve Wynn?s wife Andrea has created a ?Look of Love? menu at Andrea?s in the Encore that includes oysters and caviar. Our friend cookbook author and pastry chef Megan Romano has chocolate-dipped strawberries, chocolate champagne truffles and chocolate raspberry tortes at her Chocolate & Spice on West Sahara.
Chef and Michelin Star winner Guy Savoy has flown in from Paris to serve his 10-course meal, also including oysters and caviar. Gordon Ramsay has caviar on his four-course menu with the Scotch eggs. Serendipity 3 at Caesars Palace offers an ?Adam and Eve Menu? that includes Garden of Eden sweetheart delights with Aphrodite angel hair and ends with ?Cupid?s molten chocolate.? Check out Las Vegas Sun colleague Allison Duck?s extensive Valentine?s Day dining guide.
Mandarin Oriental is offering a month of romance that includes a sultry stay. The $1,500 Suite Seduction features an art of romance spa treatment in a soaking tub for two; decadent delicacies with aphrodisiac ingredients served in the privacy of the suite; and a romance concierge who will provide candles, rose petals, music and movies from Kiki De Montparnasse at Crystals.
There?s a ?Secret Agent 702? experience for couples wanting to explore their inner sexy spy. Papillon Helicopters has a $6,800 package that includes disguises, Ferrari road-racing sports cars at Las Vegas Motor Speedway, a 3,800-feet cable zipline adventure and a 5 a.m. private helicopter tour of the Grand Canyon with champagne and strawberries for breakfast on a private plateau overlooking the Colorado River. And Eli Roth?s Goretorium gets into the mood with the debut of his Love & Music series with an all-female DJ lineup of Miss Joy, Miyuki, Crykit and the Vinylist in Baby Dolls Lounge.
The Sports Illustrated Swimsuit Issue supermodels celebrate Valentine?s Day at 1 OAK in The Mirage. Hyde Bellagio honors ?Singles Awareness Day? teamed up with Match.com to help 300 Las Vegas singles find true love on the magical night. And ladies who wear black lingerie receive a two-hour open bar at Tao?s ?Cupid Is Stupid? anti-Valentine?s party.
May love, lust and romance be with you and your significant other. The rose is red, the violet is blue, the honey is sweet, and so are you -- an English nursery rhyme from 1784 still valid today.
Robin Leach has been a journalist for more than 50 years and has spent the past decade giving readers the inside scoop on Las Vegas, the world?s premier platinum playground.
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